A visitor asked about an unusual side effect of increasing Wellbutrin (bupropion) dosage from 150 to 300 mg: increased libido.
I looked at the package insert (prescribing information that the FDA approves for a drug) and didn’t see increased libido in the side effect profiles, including the rare side effect profiles. I did a medline search and saw a couple of case reports of hypersexuality from bupropion:
J Clin Psychiatry. 2003 Oct;64(10):1268-9. “Effect of bupropion on sexual dysfunction induced by fluoxetine: a case report of hypersexuality.” Chollet CA, Andreatini R.
Publication Types:
* Case Reports
* Letter
PMID: 14658981 [PubMed - indexed for MEDLINE]
Can J Psychiatry. 1998 Aug;43(6):644-5. “Bupropion-SR-induced increased libido and spontaneous orgasm.” Labbate LA.
Publication Types:
* Case Reports
* Letter
PMID: 9729695 [PubMed - indexed for MEDLINE]
I wanted to see if anyone either knows additional information about this or have experienced this. Wellbutrin is often prescribed for those concerned with the sexual side effects of SSRI-type of drugs, and the low incidence of sexual side effect is a feature of this drug that the manufacturer markets to physicians. However, I’m not aware of this drug increasing libido to a debilitating level.
Can anyone help with this visitor’s question?
Jane,
Just began on bupropion for depression…side effect was increase in my naturally decreased libido. I am 42 years old, have always had high libido until recently, and attributed it to my age. I have a level of sexual response much like that before it began to slowly decrease in past few years. I am all for it in helping women’s libidos.
It does have the caffeine effect, and makes it hard to sleep, but it has only been ten days.
Sincerely,
Yvette
Yvette -
Thanks for your feedback. I agree with you about helping women’s libidos - there aren’t many options out there for women as opposed to the various drugs advertised for mens’ sexual dysfunction.
Do you take it early in the morning? Bupropion is definitely “activating” and in the past when I took it, I took it in the morning.
Best wishes,
Jane
I was prescribed Wellbutrin because 3 other antidepressants I’ve tried “diabled” my ability to reach orgasm. I have definitely experienced the libido lift of Wellbutrin, overly so, even. I’ve also experienced sleeplessness - which is NOT me, and night sweats.
I’m taking the wellbutrin XL (extended release). only 150, just got raised to 300. I take it before I go to bed because I have the tendency to get tired after I ingest a pill.
Yes, I sleep less (don’t miss it though, not tired). Yes, I may sweat more than usual.
And YES,YES, YES (about the other thing)
Today I Googled sexual side effects of Wellbutrin XL after being on it for 2 weeks now. The first week I was on 150mg and starting at the beginning of the second week have been on 300mg. Not only is it helping with my depression, my formerly non-existant libido has returned to “normal.” Now I have another problem… Most of my depression revolves around the fact that I don’t like my husband because he is emotionally abusive. Now I’m horney but married to a man that I really don’t want to do it with. What’s a girl to do?
Kathy, do you need someone to approve what you are planning? OK, then.
Cheat on your husband, or dump his sorry ass. Maybe cheat on him, and then leave him when you’ve found a real man.
Or you can stay with him until he learns not to be abusive. Hahahahahaha. Just kidding. That never happens.
I’m taking Welbutrin 300 mg.. And also on Paxil.. The problem I have is I am unable to ejaculate.. I would think it was the paxil, but I was taking only 5 mg of paxil only and sometimes could ejaculate sometimes not.. I went back on the Welbutrin and trying to stop the paxil. Went from 5mg to 2.5 mg.. Since I’m on the welbutrin, Can’t ejaculate at all..
Any Ideas? Any Medications I can add to help with this?? I don’t think Vigra will help.. LOL
[...] made the following comment regarding his experience with two antidepressants: I’m taking Welbutrin 300 mg.. And also on [...]
I am a 40 year old male. I just increased my wellbutrin from 300 to 450 a day and my libido is through the roof. I guess it effects everyone differently, but for me it makes me want to have sex all the time,
Robert
Oh My Goddess!~
increased libido??!?!?!?!?! mine has so increased i didn’t think a libido could get that big!~(lol).
Anyways, let me be serious for a minute about MY personal condition:
I have been diagnosed ptsd and borderline bipolar…
I was put on Wellbutrin SR and Seroquel 300 @ 3 years ago…
The Seroquel is WAAAAAY too strong for me to take an entire pill at bedtime…but concerning the Wellbutrin—
…i have found (And i would REALLY like it if you
could get back to me personally when I’m through here, so I can tell you some very,very interesting things about Wellbutrin)that my depression has been somewhat alleviated as long as i stay on my regimen of Buproprion…my mood is now generally “up”-ee and I sometimes feel the SLIGHTEST little bit of self-esteem coming back to me…But here is the answer you asked us for—Sexual Libido increase w/ Wellbutrin?
YES YES YES YES YES YES YES OMIGODYES YES YES…I’M A WALKING ORGASM…i’m sorry i don’t mean 2 offend you…but 100% honestly, i have never , ever in my whole 42 years on this planet,felt soooooo darn horny All the Time!~i get a little “tingle” in my u-no-where area and it stays there alllll day!` I have actually followed these amazing feelings and they have taken me to OOhhhh boy ooooh boy….places i never thought i could EVER discover!~this is why u must Email me back personally…i would love to share w/ you my experiences while
on Buproprion…which i might add, i have been changed over to the Wellbutrin XL…and oh boy…even worse!!!..or better-it’s in the way you decide .
ive just recently started taking wellbutrin for my depression and found four distinct affects,an elivated mood elivated labido alot of energy and pain relief in my stomach from a hernia and im only taking 100 mg a day go figure!
I have been on Wellbutrin for 8 years. LIBIDO stays but not as strong as it was at first. It is a great anti depressant. Love my WELLBUTRIN XL!!
I consider Wellbutrin XL to be a wonder drug for brain chemistry depression (added the descriptors as some people don’t know the difference between chronic and temporary depression.) I am productive and I can hold a job. And although I don’t believe I am hypomanic at all, (I have bipolar depression,) I do have the hypersexual side effect that is usually attributed to a hypomanic mood swing. I’m an odd case though — diagnosed bipolar disorder I, the strongest level, yet I don’t have mood swings anymore. I healed. Just chronic depression, which the Wellbutrin XL fixes. However, the hypersexuality is a problem, and I have even started going to a Sex Addicts Anonymous group as a result. For me the main problem is instead of having sex with my wife, I prefer to satisfy an appetite for fantasy, yet I do that safely, using free internet porn movies. It is a problem as then the hypersexuality just gets worse when you are watching porn. The porn seems to act as a persuasive element that then just creates more appetite and makes you look at women and teenage girls as sex objects. Even when your morality dictates otherwise. I can be irritable also I think, but it takes someone else’s temper usually to set mine off, or it takes a lot of stress. I probably should take another anti depressant with wellbutrin to temper the effect of the libido, as most others have the opposite affect on libido. While it can’t hurt to boost multiple brain chemicals regarding treating depression.
I wish my husband would look at this issue. He has always been more into fantasy through porn but this has seemed to result from his dysfunctional family system. As a result, I think it’s become somewhat an addiction for him. I also know that depression runs in his family. He has never wanted to investigate whether the depression and the escape porn provides may be linked in some way. I, personally, have nothing against porn as an addendum to sex with another person, but when it replaces that sexual connection with a person, it’s destructive to the relationship. Well, I saw your email and it gave me pause when you mentioned the link between depression and sexual addiction. If anything you have tried has been successful in addition to the medication, I’d be interested in hearing your perspective on it.
Thank you! Jeannie
I was prescribed on Citalopram about a year and a half ago for panic attacks. I recently noticed, maybe two or three months ago that it was very difficult to reach an orgasm. My doc put me on wellbutrin, and my libido went through the roof!!! I was reaching orgasm two sometimes three times a day, in a matter of just hours too. I’m 24 and have never been able to ejaculet 3 times in 6 hours, until then, which is fantastic because my wife and I are very sexual beings. However, about two weeks ago, my libido disappeared, and I have since grown somewhat depressed. I have had no desire at all to have sex. This is very difficult because my wife is upset, she feels as though it is her, AND IT’S NOT!!! I am more than happy to satisfy her in other ways, but she refuses, she wants to make love. So often times I try to give her what she needs and it leads to nothing but heart break for both of us, I can’t get get excited, she thinks it’s her, and I’m upset because I have not only upset my wife emotionally as she thinks i am not attracted to her, but I am unable to satisfy her sexually as well, which fuels my depression. I talked to my doc and he raised my dosage from 150mg a day to 300mg a day, he thinks this will boost my libido and my wife and I can have our fantastic sex life back. Anyone experienced anything similar to this, with the dosage increase or what not……..DID IT WORK?!?!?!?!?!?!?!