U.S. Food and Drug Administration (FDA) published a warning that mixing certain sSRI/SNRI-type of antidepressant medications and triptan-based migraine drugs may cause a potentially lethal condition called Serotonin Syndrome.

According to the FDA website, when the body has too much serotonin, symptoms of Serotonin Syndrome will occur. These symptoms may include restlessness, hallucinations, loss of coordination, fast heart beat, rapid changes in blood pressure, increased body temperature, overactive reflexes, nausea, vomiting, and diarrhea. Usually symptoms happen when the drug dose is increased or when the patient is started on the drug.

The FDA website listed some commonly prescribed drugs within the classes at risk:

SSRIs and a Combination Drug Containing an SSRI
* Celexa (citalopram)
* Fluvoxamine
* Lexapro (escitalopram)
* Paxil (paroxetine)
* Prozac (fluoxetine)
* Symbyax (olanzapine/fluoxetine)
* Zoloft (sertraline)

SNRIs
* Cymbalta (duloxetine)
* Effexor (venlafaxine)

Triptans
* Amerge (naratriptan)
* Axert (almotriptan)
* Frova (frovatriptan)
* Imitrex (sumatriptan)
* Maxalt and Maxalt-MLT (rizatriptan)
* Relpax (eletriptan
* Zomig and Zomig ZMT(zolmitriptan)