Mental Health
Cymbalta v. Lexapro Head-to-Head Study
This may speak more to my ignorance of intracies of antidepressant clinical study design - but why did Eli Lilly choose a head to head (H2H) study with Lexapro - an SSRI class antidepressant - instead of another SNRI like Effexor? Google News / Google Search
Whatever the reasons may be, there were no significant differences in efficacy between the two drugs although there are some safety differences (more dry mouth and nausea on the Cymbalta arm than sugar pill or Lexapro arm). The study was a double-blind radomized placebo controlled trial, which gives a high level of clinical confidence (i.e. how much you can trust the results of the study as true results and not because of other factors including biases or spurious effects). At the very least it means patients with depression have another drug that works so that if one cannot tolerate the side effects of a drug, there are others to choose from.
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